Understanding Muscle Weakness and Loss with Aging
The function of post-translational modifications of myosin and its chaperone UNC-45 that occur with adult aging
['FUNDING_R01'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-11193522
This research looks into the chemical changes in muscle proteins that contribute to the loss of muscle strength and mass as people get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-11193522 on ClinicalTrials.gov |
What this research studies
As we age, many people experience a natural decline in muscle mass and strength, a condition called sarcopenia, which can make daily activities harder. This project explores how certain proteins in our muscles, specifically myosin and its helper protein UNC-45, change chemically over time. We believe these age-related changes affect how these proteins work together, leading to weaker muscles. By studying these molecular changes, we hope to uncover the root causes of muscle decline in older adults.
Who could benefit from this research
Good fit: This foundational research is relevant to adults, especially those over 80 years old, who are affected by or at risk of age-related muscle loss and weakness.
Not a fit: Patients whose muscle loss is due to underlying diseases rather than natural aging may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat sarcopenia, helping older adults maintain their muscle strength and quality of life.
How similar studies have performed: Preliminary studies have shown promising correlations, and this project uses a novel combination of techniques to further explore these mechanisms.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OBERHAUSER, ANDRES F. — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: OBERHAUSER, ANDRES F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.