Understanding muscle problems caused by statin medications using patient-specific cells
Patient-specific modeling of metabolic dysfunction in statin-induced myopathy using iPSC-derived myocytes
This study is looking into how statin medications, which help lower cholesterol, might cause muscle pain and weakness in some people, using special lab-grown muscle cells to better understand why these side effects happen and how they can vary from person to person.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10888349 on NIH RePORTER |
What this research studies
This research investigates how statin medications, commonly used to lower cholesterol, can lead to muscle-related issues such as discomfort and weakness. By utilizing patient-specific induced pluripotent stem cells (iPSCs) to create muscle cells, the study aims to uncover the mechanisms behind statin-induced myopathy. The researchers will explore how these medications affect muscle cell metabolism and lead to cell death, which could help identify why some patients experience severe side effects. This approach allows for a more personalized understanding of how statins impact individuals differently.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced muscle pain or weakness while taking statin medications.
Not a fit: Patients who have never taken statins or do not experience any muscle-related side effects from these medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients who experience muscle pain from statin use, enhancing medication adherence and overall cardiovascular health.
How similar studies have performed: Previous research has indicated potential mechanisms of statin-induced myopathy, but this study aims to validate these findings using innovative patient-specific models, making it a novel approach.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Rhee, June-Wha — Beckman Research Institute/city of Hope
- Study coordinator: Rhee, June-Wha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.