Understanding muscle loss and rehabilitation after severe injuries

Pathological Foundations of Skeletal Muscle After Volumetric Muscle Loss and Targets For Rehabilitation

['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-11053508

This study is looking at how losing muscle affects recovery and movement, so we can find better ways to help people with muscle loss get back to their normal activities.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF GEORGIA (nih funded)
Locations1 site (ATHENS, UNITED STATES)
Trial IDNIH-11053508 on ClinicalTrials.gov

What this research studies

This research investigates the effects of volumetric muscle loss (VML) on skeletal muscle and its implications for rehabilitation. It aims to understand how the remaining muscle tissue responds to injury and the challenges patients face in regaining mobility and function. By examining the biological signals and mechanisms involved, the study seeks to identify new targets for improving rehabilitation outcomes for individuals with VML. Patients may be involved in assessments that explore their muscle function and rehabilitation responses.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have experienced volumetric muscle loss due to trauma or surgical amputation.

Not a fit: Patients with muscle injuries that do not involve volumetric muscle loss may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved rehabilitation strategies that enhance recovery and mobility for patients with severe muscle injuries.

How similar studies have performed: Previous research has shown promise in understanding muscle regeneration and rehabilitation, but this specific approach to VML is relatively novel.

Where this research is happening

ATHENS, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.