Understanding muscle loss after severe burn injuries
Official title: Cellular and Molecular Determinants of Post-Burn Myopathy
Funded at University of Kentucky · NIH-11141215 · Data updated 2026-11-12
This study is looking at how severe burn injuries can cause muscle loss and weakness, and it hopes to find new ways to help people keep their muscles strong and healthy after such injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $368,964 |
| NIH project number | 5R35GM155281-02 |
| Project ID | NIH-11141215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe burn injuries and are facing challenges related to muscle atrophy.
✕Less likely to help
Patients who have not suffered severe burn injuries or those with unrelated muscle disorders may not benefit from this research.
What this research studies
This research investigates the cellular and molecular factors that contribute to muscle atrophy and weakness following severe burn injuries. It aims to explore how burn trauma disrupts cell-to-cell signaling pathways, leading to long-term muscle dysfunction. The study will utilize advanced techniques, including multi-omic approaches, to identify key mediators of muscle fibrosis and assess potential therapeutic targets. Patients may benefit from insights that could lead to new treatments aimed at preserving muscle size and function post-injury.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that help maintain muscle strength and function in burn survivors.
How similar studies have gone: Previous research has shown promising results in understanding muscle regeneration and signaling pathways in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Owen, Allison M. — University of Kentucky
- Study coordinator: Owen, Allison M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.