Understanding Muscle and Bone Weakness as We Age
PROJECT 2 - Kyn-AhR interactions modulating muscle-bone crosstalk with aging
This project aims to discover why muscles and bones weaken with age, leading to conditions like sarcopenia and osteoporosis.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11103309 on NIH RePORTER |
What this research studies
As we get older, many of us experience a natural loss of muscle and bone strength, which can lead to falls and fractures. These issues significantly impact our health and quality of life. This project explores how a natural body chemical called kynurenine, which increases with age, might be causing these changes by affecting how our muscles and bones communicate. By understanding these basic processes, we hope to find new ways to keep our bodies strong as we age.
Who could benefit from this research
Good fit: This research is relevant for adults, particularly those aged 21 and older, who are interested in understanding the biological processes behind age-related muscle and bone conditions.
Not a fit: Patients seeking immediate clinical interventions or direct participation in a treatment trial would not find direct benefit from this foundational molecular research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or strategies to prevent or reverse age-related muscle and bone loss, improving health and reducing the risk of falls and fractures in older adults.
How similar studies have performed: This project builds upon preliminary data that strongly supports its central idea, suggesting a novel approach to understanding age-related muscle and bone changes.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Hamrick, Mark W — Augusta University
- Study coordinator: Hamrick, Mark W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.