Understanding muscle and bone loss in people with HIV and aging.
Official title: Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging.
Funded at Augusta University · NIH-11059051 · Data updated 2026-11-12
This study is looking at how HIV and long-term treatment for it can lead to muscle and bone loss in older adults, and it hopes to find ways to better understand and improve health for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $621,147 |
| NIH project number | 5R01AR082307-03 |
| Project ID | NIH-11059051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults living with HIV who are undergoing antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates how HIV infection and long-term antiretroviral therapy (ART) contribute to muscle and bone loss, particularly in older adults. It aims to uncover the cellular and molecular mechanisms behind these changes, focusing on the role of the aryl hydrocarbon receptor (AhR) in muscle atrophy and bone loss. By studying these processes, the research seeks to improve our understanding of frailty and related health issues in HIV patients, ultimately aiming to enhance clinical practices and patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for muscle and bone health in patients living with HIV, particularly as they age.
How similar studies have gone: Previous research has shown promising results in understanding the role of AhR in aging and muscle atrophy, indicating that this approach may yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Mcgee-Lawrence, Meghan E. — Augusta University
- Study coordinator: Mcgee-Lawrence, Meghan E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.