Understanding muscle and bone loss in people with HIV and aging.
Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging.
This study is looking at how HIV and long-term treatment for it can lead to muscle and bone loss in older adults, and it hopes to find ways to better understand and improve health for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11059051 on NIH RePORTER |
What this research studies
This research investigates how HIV infection and long-term antiretroviral therapy (ART) contribute to muscle and bone loss, particularly in older adults. It aims to uncover the cellular and molecular mechanisms behind these changes, focusing on the role of the aryl hydrocarbon receptor (AhR) in muscle atrophy and bone loss. By studying these processes, the research seeks to improve our understanding of frailty and related health issues in HIV patients, ultimately aiming to enhance clinical practices and patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults living with HIV who are undergoing antiretroviral therapy.
Not a fit: Patients who are not living with HIV or who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for muscle and bone health in patients living with HIV, particularly as they age.
How similar studies have performed: Previous research has shown promising results in understanding the role of AhR in aging and muscle atrophy, indicating that this approach may yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Mcgee-Lawrence, Meghan E. — Augusta University
- Study coordinator: Mcgee-Lawrence, Meghan E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.