Understanding multi-organ failure in children with congenital heart disease
Official title: Systems biology of acute and chronic multi-organ failure in children with congenital heart disease
Funded at University of Colorado Denver · NIH-10805817 · Data updated 2026-11-12
This study is looking at how and why some children with congenital heart disease experience problems with multiple organs after surgery, so we can find better ways to help them recover and stay healthy in the long run.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $126,059 |
| NIH project number | 1K24HL167910-01A1 |
| Project ID | NIH-10805817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have congenital heart disease and are undergoing surgical interventions.
✕Less likely to help
Patients with congenital heart disease who are not undergoing surgical interventions or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the complex biological mechanisms behind acute and chronic multi-organ failure in children with congenital heart disease (CHD). By utilizing advanced diagnostic techniques that measure numerous biological markers simultaneously, the study aims to uncover the underlying causes of postoperative complications in these patients. The research will focus on two established patient groups: those undergoing neonatal surgery and those receiving staged palliation for single ventricle heart disease. The goal is to improve our understanding of how these children recover and to identify potential interventions that could enhance their long-term health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better health outcomes for children with congenital heart disease.
How similar studies have gone: Previous research using similar 'omics' approaches has shown promise in understanding complex diseases, suggesting that this methodology could yield valuable insights in this context.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Davidson, Jesse — University of Colorado Denver
- Study coordinator: Davidson, Jesse
Related research
Other NIH-funded projects on the same topics.
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-
Multimodal AI to improve genetic diagnosis of congenital heart disease
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Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains
This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.
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AI-powered echocardiography to spot common heart defects in newborns
A new AI tool analyzes infant heart ultrasound images to help non-specialist health workers identify five common, treatable heart defects early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.