Understanding movement and impulse control issues in Parkinson's Disease
Striatal Mechanisms of Dyskinesia and Impulse Control in Parkinson’s Disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11067847
This study is looking into how treatments for Parkinson's Disease, especially those that boost dopamine, can sometimes cause problems with movement and impulse control, and it aims to find ways to improve these treatments for better patient care.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11067847 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind movement disorders and impulse control issues that can arise from treatments for Parkinson's Disease. It focuses on how dopamine replacement therapies, while effective for motor symptoms, can lead to complications like abnormal involuntary movements and impulsive behaviors. Using advanced techniques such as electrophysiology and optogenetics in animal models, the study aims to uncover the cellular and circuit-level changes that contribute to these complications. This knowledge could help in developing better treatment strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's Disease who are undergoing treatment with dopamine replacement therapies.
Not a fit: Patients who are not currently receiving dopamine replacement therapies or those with early-stage Parkinson's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that minimize movement disorders and impulse control issues in Parkinson's Disease patients.
How similar studies have performed: Previous research has shown promising results in understanding levodopa-induced dyskinesia, suggesting that this approach may yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NELSON, ALEXANDRA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: NELSON, ALEXANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.