Understanding Mouth Bacteria in Children Receiving Stem Cell Treatment
Investigating the oral microbiome in hematopoietic cell transplants
This project looks at how bacteria in the mouth might contribute to infections and mouth sores in children who receive stem cell treatments.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11167589 on NIH RePORTER |
What this research studies
Children undergoing stem cell treatments often face painful mouth sores and serious bloodstream infections. These problems might be linked to changes in the bacteria living in their mouths. We want to understand if specific mouth bacteria travel into the bloodstream, causing these infections. By closely following children at Nationwide Children's Hospital, we hope to identify these connections and find better ways to prevent these complications.
Who could benefit from this research
Good fit: Ideal candidates are children who are undergoing hematopoietic cell transplant (stem cell treatment) for various diseases.
Not a fit: Patients who are not undergoing hematopoietic cell transplant would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent painful mouth sores and dangerous bloodstream infections in children after stem cell treatments.
How similar studies have performed: Previous research in adults has linked oral microbiome disruptions to complications after stem cell treatments, but this work specifically focuses on children.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Lee, Kyulim — Research Inst Nationwide Children's Hosp
- Study coordinator: Lee, Kyulim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.