Understanding motor problems in people with HIV on treatment
Motor Dysfunction in cART-era HIV: Neural Circuitry and Pathogenesis
This study is looking at why some people with HIV have trouble with movement, even when they're on treatment, by examining their brains and motor skills to find out how certain brain areas and blood vessel problems might be involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10459605 on NIH RePORTER |
What this research studies
This research investigates the causes of motor dysfunction in individuals living with HIV who are receiving combination antiretroviral therapy (cART). It aims to identify specific brain regions and molecular signatures associated with motor impairments by using advanced imaging techniques and analyzing brain tissue from autopsies. The study will recruit 160 participants to assess their motor function and brain structure, focusing on how cerebrovascular disease may contribute to these issues. By understanding the neural circuitry involved, the research hopes to shed light on the underlying mechanisms of motor dysfunction in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals who are currently receiving cART and may be experiencing motor dysfunction.
Not a fit: Patients who are not HIV-positive or those who do not have motor dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for motor dysfunction in HIV-positive individuals.
How similar studies have performed: Previous research has shown that understanding neural circuitry and molecular signatures can lead to significant insights in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Morgello, Susan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Morgello, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.