Understanding MKRN3's role in puberty and fertility
Deciphering the functional role of MKRN3 in puberty and reproduction
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11099812
This research explores how a gene called MKRN3 affects when puberty starts and how it influences reproductive health, as well as risks for adult diseases like heart conditions and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11099812 on ClinicalTrials.gov |
What this research studies
Puberty's timing is controlled by a system in the brain called the HPG axis, and it can affect your health later in life, including risks for obesity, diabetes, heart problems, and certain cancers. We know that a gene called MKRN3 is often involved when puberty starts too early. This project aims to discover exactly how MKRN3 works to control puberty's timing at a molecular and cellular level. By understanding these mechanisms, we hope to learn more about why some people experience early puberty and how it connects to other health issues.
Who could benefit from this research
Good fit: Patients who have experienced central precocious puberty or have a family history of early puberty and related conditions might find this research particularly relevant.
Not a fit: Patients whose reproductive issues are not linked to the MKRN3 gene or the timing of puberty may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict, prevent, or treat conditions related to early puberty and its associated health risks in adulthood.
How similar studies have performed: While MKRN3 mutations are recognized as a common genetic cause of central precocious puberty, this project aims to uncover the precise molecular and cellular mechanisms, building on existing genetic findings.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAISER, URSULA B. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: KAISER, URSULA B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiometabolic Disease, Cardiometabolic Disorder