Understanding mitochondrial mutations and their effects on health and aging
Causes and Consequences of Mitochondrial Mutations
This study is looking at how changes in the DNA of tiny energy-producing parts of our cells can affect how well our bodies work and stay healthy, especially when faced with things like stress from the environment, and it's for anyone interested in understanding more about energy production and aging in living organisms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11076314 on NIH RePORTER |
What this research studies
This research investigates how mutations in mitochondrial DNA affect cellular energy production and overall organism health. By studying various eukaryotic systems, including invertebrates and plants, the project aims to create a detailed atlas of mitochondrial mutations and their physiological impacts. The researchers will utilize advanced sequencing techniques to identify mutation types and rates, particularly focusing on how environmental factors like oxidative stress influence these mutations. The study also aims to quantify the effects of these mutations on metabolic processes and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to mitochondrial dysfunction or those experiencing age-related health issues.
Not a fit: Patients with non-genetic health issues unrelated to mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the role of mitochondrial mutations in diseases and aging, potentially informing future treatments.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial mutations in mammalian models, but this approach in diverse eukaryotic systems is relatively novel.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Havird, Justin C — University of Texas at Austin
- Study coordinator: Havird, Justin C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.