Understanding migraine onset in adolescent girls
Official title: Migraine Onset in Adolescent Girls
Funded at Washington University · NIH-11005690 · Data updated 2026-11-12
This study is looking at what might trigger migraines in girls aged 10 to 13, focusing on things like hormones and family history, to help find ways to predict and possibly prevent these headaches.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $576,773 |
| NIH project number | 5R01NS129742-03 |
| Project ID | NIH-11005690 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are healthy girls aged 10 to 13, particularly those with a family history of migraines.
✕Less likely to help
Patients outside the age range of 10 to 13 or those who are male may not receive benefit from this research.
What this research studies
This research investigates the factors that contribute to migraine onset specifically in adolescent girls aged 10 to 13. It aims to identify psychophysical and neural predictors of migraine, as well as hormonal and other changes associated with the onset of migraines. The study will involve healthy participants with and without a family history of migraines to better understand the differences in migraine development. By analyzing these factors, the research seeks to provide insights into how migraines can be predicted and potentially prevented.
Why it matters
Potential benefit: If successful, this research could lead to improved prediction and prevention strategies for migraines in adolescent girls.
How similar studies have gone: Preliminary data suggests that similar approaches have shown promise in identifying predictors of migraine onset, indicating potential for success in this research.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Nahman-Averbuch, Hadas — Washington University
- Study coordinator: Nahman-Averbuch, Hadas
Related research
Other NIH-funded projects on the same topics.
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Meningeal pain and migraine brain hyperexcitability in people
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Mi-Helper: a drug-free air-based device to relieve migraine pain
A new, drug-free device uses a gentle stream of dry air to calm migraine symptoms, aimed at people visiting emergency departments.
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A basic science project to explore how blocking S1PR1 could help people who have both migraine and temporomandibular disorders by studying pain pathways in animal models.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.