Understanding Metabolism and Immune Health in Older Adults with HIV
Metabolic deficits and immune dysfunction in aging people living with HIV
This project explores how metabolism and immune system changes affect older adults living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11126898 on NIH RePORTER |
What this research studies
Aging and HIV both contribute to ongoing inflammation and immune system activation, which can weaken the body's defenses against infections and vaccines. These conditions also bring about metabolic changes, impacting how the body uses sugar and fats, and how cells produce energy. We believe that as people with HIV get older, these metabolic shifts make their immune systems work less effectively. Our goal is to uncover the specific ways these energy pathways are affected in immune cells, which could help us find new ways to support immune health.
Who could benefit from this research
Good fit: This research is relevant for older adults living with HIV who experience chronic inflammation and immune system changes.
Not a fit: Patients who are not living with HIV or are not in an older age group may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to improve immune function and overall health for older individuals living with HIV.
How similar studies have performed: Preliminary results support the hypothesis that aging worsens immune defects through metabolic changes, especially in people with HIV.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Frasca, Daniela — University of Miami School of Medicine
- Study coordinator: Frasca, Daniela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.