Understanding metabolic changes in aging and Alzheimer's disease during surgery
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
This study looks at how aging and Alzheimer's disease change the way our brains and blood work during surgery with anesthesia, using mice to find out what these changes are and if certain treatments can help protect against them, which could lead to better ways to diagnose Alzheimer's in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012356 on NIH RePORTER |
What this research studies
This research investigates how aging and Alzheimer's disease (AD) affect metabolic changes in the brain and blood during surgical procedures under anesthesia. By using advanced imaging techniques in mouse models, the study aims to identify specific metabolic alterations associated with AD and aging. The researchers will also explore the potential protective effects of certain interventions on these metabolic changes. This work is crucial for developing non-invasive diagnostic tools for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of Alzheimer's disease or those at risk due to age-related factors.
Not a fit: Patients with non-neurological conditions or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods for Alzheimer's disease, allowing for earlier and more accurate detection.
How similar studies have performed: Previous research has shown promising results in using metabolic profiling for understanding Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Jenkins, Bruce G — Massachusetts General Hospital
- Study coordinator: Jenkins, Bruce G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.