Understanding metabolic changes and oxidative stress in brain injury after oxygen deprivation
Metabolic Landscape and Mitochondrial ROS Balance in Brain Ischemia/Reperfusion
This study looks at how brain injuries from a lack of oxygen at birth can change the way the brain uses energy and create harmful stress, with the goal of finding new ways to help treat these injuries and improve care for affected babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004297 on NIH RePORTER |
What this research studies
This research investigates the metabolic alterations and oxidative stress that occur in the brain following ischemia-reperfusion injury, particularly after perinatal asphyxia. By examining how disruptions in metabolic pathways like glycolysis and the TCA cycle contribute to oxidative stress, the study aims to identify potential therapeutic strategies. The research will focus on the role of reactive oxygen species (ROS) and how their imbalance can lead to further brain injury. Patients may benefit from insights gained into these mechanisms, which could inform future treatments for brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced brain injuries, particularly those related to ischemia-reperfusion events.
Not a fit: Patients with chronic neurological conditions unrelated to ischemia-reperfusion injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to mitigate neurological disabilities caused by brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways related to oxidative stress in brain injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Galkin, Alexander — Weill Medical Coll of Cornell Univ
- Study coordinator: Galkin, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.