Understanding metabolic changes and oxidative stress in brain injury after oxygen deprivation
Official title: Metabolic Landscape and Mitochondrial ROS Balance in Brain Ischemia/Reperfusion
Funded at Weill Medical Coll of Cornell Univ · NIH-11004297 · Data updated 2026-11-12
This study looks at how brain injuries from a lack of oxygen at birth can change the way the brain uses energy and create harmful stress, with the goal of finding new ways to help treat these injuries and improve care for affected babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $463,608 |
| NIH project number | 5R01NS131322-02 |
| Project ID | NIH-11004297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced brain injuries, particularly those related to ischemia-reperfusion events.
✕Less likely to help
Patients with chronic neurological conditions unrelated to ischemia-reperfusion injury may not benefit from this research.
What this research studies
This research investigates the metabolic alterations and oxidative stress that occur in the brain following ischemia-reperfusion injury, particularly after perinatal asphyxia. By examining how disruptions in metabolic pathways like glycolysis and the TCA cycle contribute to oxidative stress, the study aims to identify potential therapeutic strategies. The research will focus on the role of reactive oxygen species (ROS) and how their imbalance can lead to further brain injury. Patients may benefit from insights gained into these mechanisms, which could inform future treatments for brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to mitigate neurological disabilities caused by brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways related to oxidative stress in brain injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Galkin, Alexander — Weill Medical Coll of Cornell Univ
- Study coordinator: Galkin, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.