Understanding metabolic changes after brain hemorrhage

Who could benefit from this research

What this research studies

This research investigates the metabolic alterations that occur following an aneurysmal subarachnoid hemorrhage (aSAH), a serious condition affecting the brain. The study aims to identify how these metabolic changes relate to systemic inflammation and the risk of complications such as delayed cerebral ischemia. By analyzing plasma samples from patients with aSAH, researchers will define a metabolic signature that could help predict patient outcomes. The approach involves advanced techniques like mass spectrometry to measure specific metabolites in the blood.

Why it matters

Where this research is happening

• University of Texas Hlth Sci Ctr Houston
  Houston, United States Active

Researchers

• Principal investigator: Gusdon, Aaron Mark — University of Texas Hlth Sci Ctr Houston
• Study coordinator: Gusdon, Aaron Mark

Related research

Other NIH-funded projects on the same topics.

• Cognitive screening after an aneurysmal brain bleed

  Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11468520

• Molecularly mapping early brain injury after brain bleed using human brain organoids and patient CSF

  Scientists are studying how early brain injury after aneurysmal subarachnoid hemorrhage happens in people, by using patient CSF and human brain organoids to find what signals cause damage and why women may have worse outcomes.

  NIH research Barrow Neurological Institute at St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-11290705

• Using Satralizumab to treat complications from brain aneurysms.

  This study is looking at how well the drug Satralizumab can help people recover after a brain aneurysm by reducing complications like vasospasm, and it’s designed for patients who have had this type of hemorrhage.

  NIH research University of Florida · Gainesville, United States · NIH-10952347

• Identifying brain injury risks in patients with aneurysmal subarachnoid hemorrhage using brain activity monitoring.

  This study is looking at how to better manage blood pressure for people who have had a brain bleed from an aneurysm, by closely monitoring their brain activity to find the best targets for blood flow, which could help prevent further complications and improve recovery.

  NIH research Yale University · New Haven, United States · NIH-10821463

• Improving cognitive assessment after brain hemorrhages for better patient outcomes

  This study is looking to improve how we spot and understand thinking problems in people who have had a brain bleed, especially focusing on African American and rural patients who might not get the help they need, so we can help them live better lives.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10789774

• Blood test to predict delayed brain injury after an aneurysm bleed

  This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11467911

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.