Understanding Mesh Complications in Pelvic Organ Prolapse Repair
Official title: Mesh complications: The role of local mechanical stresses on tissue remodeling following mesh implantation
Funded at Magee-Women's Res Inst and Foundation · NIH-11145845 · Data updated 2026-11-12
This research explores how the design and placement of surgical mesh contribute to complications like pain and mesh exposure in women who have had pelvic organ prolapse surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | August 15, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $455,742 |
| NIH project number | 5R01HD083383-10 |
| Project ID | NIH-11145845 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant to women who have undergone or may undergo surgery for pelvic organ prolapse, especially those who have experienced or are at risk for mesh-related complications.
✕Less likely to help
Patients not affected by pelvic organ prolapse or surgical mesh complications would not directly benefit from this specific research.
What this research studies
Many women undergo surgery for pelvic organ prolapse, often using surgical mesh to help with repair. However, some women experience complications such as mesh exposure or ongoing pain. This project aims to understand why these problems happen by looking closely at how different mesh designs and the stresses on the mesh affect the surrounding body tissues. We want to learn how the mesh interacts with the body to cause issues like tissue thinning or excessive scar tissue formation. By understanding these mechanisms, we hope to find ways to prevent these complications in the future.
Why it matters
Potential benefit: If successful, this work could lead to improved surgical mesh designs and techniques, ultimately reducing complications and improving the quality of life for women undergoing pelvic organ prolapse repair.
How similar studies have gone: Previous work using laboratory tests and computer models has shown that mesh pore stability affects outcomes, suggesting this approach of studying mechanical stresses is promising.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Moalli, Pamela a. — Magee-Women's Res Inst and Foundation
- Study coordinator: Moalli, Pamela a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.