Understanding memory problems in temporal lobe epilepsy
Official title: Cell Type-Specific Transcriptional Changes Underlying Memory Impairment in Temporal Lobe Epilepsy
Funded at University of California Los Angeles · NIH-10876402 · Data updated 2026-11-12
This study is looking at how changes in brain cells might affect memory in people with temporal lobe epilepsy, using mice to help find ways to improve memory for those who have this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $240,474 |
| NIH project number | 5K08NS123509-03 |
| Project ID | NIH-10876402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience memory impairment.
✕Less likely to help
Patients without temporal lobe epilepsy or those whose memory issues are unrelated to epilepsy may not benefit from this research.
What this research studies
This research investigates how specific changes in brain cells contribute to memory impairment in patients with temporal lobe epilepsy (TLE). By studying a mouse model of TLE, the researchers aim to identify the cellular and molecular mechanisms that lead to memory dysfunction. They believe that understanding these processes could reveal critical time points for potential therapeutic interventions to improve memory. The study focuses on the reorganization of brain circuits and how this affects memory function over time.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory function in patients with temporal lobe epilepsy.
How similar studies have gone: Previous research has shown promise in understanding memory dysfunction in epilepsy, but this specific approach focusing on circuit reorganization is relatively novel.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Ho, Victoria — University of California Los Angeles
- Study coordinator: Ho, Victoria
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.