Understanding memory problems in temporal lobe epilepsy
Cell Type-Specific Transcriptional Changes Underlying Memory Impairment in Temporal Lobe Epilepsy
This study is looking at how changes in brain cells might affect memory in people with temporal lobe epilepsy, using mice to help find ways to improve memory for those who have this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10876402 on NIH RePORTER |
What this research studies
This research investigates how specific changes in brain cells contribute to memory impairment in patients with temporal lobe epilepsy (TLE). By studying a mouse model of TLE, the researchers aim to identify the cellular and molecular mechanisms that lead to memory dysfunction. They believe that understanding these processes could reveal critical time points for potential therapeutic interventions to improve memory. The study focuses on the reorganization of brain circuits and how this affects memory function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience memory impairment.
Not a fit: Patients without temporal lobe epilepsy or those whose memory issues are unrelated to epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory function in patients with temporal lobe epilepsy.
How similar studies have performed: Previous research has shown promise in understanding memory dysfunction in epilepsy, but this specific approach focusing on circuit reorganization is relatively novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Ho, Victoria — University of California Los Angeles
- Study coordinator: Ho, Victoria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.