Understanding memory problems in Alzheimer's disease
Dissociating the mechanisms of Tau PET and cortical atrophy underlying memory deficits in typical and atypical prodromal Alzheimer's disease
This study is looking at how certain proteins in the brain affect memory problems in people with Alzheimer's disease, especially in the early stages, to help us understand how these issues develop and improve care for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10805380 on NIH RePORTER |
What this research studies
This research investigates how different factors, such as amyloid and tau proteins, contribute to memory issues in people with typical and atypical Alzheimer's disease, particularly during the mild cognitive impairment stage. By examining both memory encoding and storage, the study aims to identify specific brain changes that affect memory function. Patients will be assessed using imaging techniques to track these changes over time, helping to clarify how memory deficits develop and progress in Alzheimer's. The ultimate goal is to enhance the ability to predict outcomes and improve care for individuals with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mild cognitive impairment who exhibit symptoms of typical or atypical Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding memory deficits related to Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Putcha, Deepti — Massachusetts General Hospital
- Study coordinator: Putcha, Deepti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.