Understanding Memory Loss in Aging and Alzheimer's Disease
Tracking the onset of spatial memory deficits in aging and Alzheimers disease models with single neuron resolution electrophysiology
This project looks closely at how brain cells change with age and in Alzheimer's disease to understand why memory problems start.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11124815 on NIH RePORTER |
What this research studies
We want to understand how memory loss begins in older adults and those with Alzheimer's disease. Researchers are using advanced technology to observe individual brain cells and their connections over time in models of aging and Alzheimer's. This involves studying how brain regions important for memory, like the hippocampus, change. We are also exploring the role of a protein called tau, which is linked to Alzheimer's, to see how it affects brain cell function and memory.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the disease mechanisms and does not directly involve patient participation at this stage.
Not a fit: Patients not experiencing age-related memory decline or Alzheimer's disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help us understand the earliest changes in the brain that lead to memory loss, potentially leading to new ways to prevent or treat Alzheimer's disease.
How similar studies have performed: This project uses a novel mesh electronics technology to overcome previous challenges in studying single neurons, making its approach quite innovative.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zwang, Theodore Joseph — Massachusetts General Hospital
- Study coordinator: Zwang, Theodore Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.