Understanding memory loss and brain changes related to aging and TDP-43 pathology
Characterizing TDP-43 related hippocampal degeneration and memory loss in aging
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-10884997
This study is looking at how a protein called TDP-43 impacts memory and brain health in older adults, especially those with Alzheimer's and other memory-related issues, to better understand how changes in a key part of the brain affect thinking and memory.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10884997 on ClinicalTrials.gov |
What this research studies
This research investigates how TDP-43 pathology affects memory and brain health in older adults. It aims to understand the specific changes in the hippocampus, a critical area for memory, and how these changes relate to cognitive decline. By examining brain samples and using advanced imaging techniques, the study seeks to clarify the relationship between TDP-43 and memory impairment, particularly in the context of Alzheimer's disease and other age-related dementias.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing memory loss or cognitive decline, particularly those with or at risk for Alzheimer's disease.
Not a fit: Patients with memory loss due to non-age-related causes or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for memory loss associated with aging and Alzheimer's disease.
How similar studies have performed: Previous research has shown that understanding TDP-43 pathology can provide insights into neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNEIDER, JULIE A. — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: SCHNEIDER, JULIE A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome