Understanding memory decline in aging and early Alzheimer's disease
Hippocampal-dependent memory decline in aging and early Alzheimer's disease
This study is looking at how Alzheimer's disease affects memory in older adults who are still doing well mentally, and it aims to find early signs that could help predict who might be at risk for memory problems in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11021104 on NIH RePORTER |
What this research studies
This research investigates how Alzheimer's disease (AD) affects memory in older adults, particularly focusing on the early stages of the disease before significant cognitive impairment occurs. By utilizing advanced neuroimaging techniques and analyzing cerebrospinal fluid, the study aims to identify the biological markers associated with memory decline. The research will involve a cohort of older adults who are clinically unimpaired, with an emphasis on including diverse participants to enhance the findings' applicability. The goal is to better understand the mechanisms of memory decline and improve predictions of individual risk for developing Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are clinically unimpaired but may be at risk for Alzheimer's disease due to age or family history.
Not a fit: Patients who are already diagnosed with Alzheimer's disease or have significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using neuroimaging and biomarker analysis to understand Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mormino, Elizabeth — Stanford University
- Study coordinator: Mormino, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.