Understanding Memory Changes in Temporal Lobe Epilepsy
Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy
This project looks for clues in the body that can help us understand why some adults with temporal lobe epilepsy experience memory problems while others do not.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11136422 on NIH RePORTER |
What this research studies
Temporal lobe epilepsy (TLE) is a common cause of seizures in adults and can often lead to memory difficulties, which impact daily life. Interestingly, some people with severe TLE and brain damage still maintain good memory, and we don't fully understand why these differences occur. This project aims to discover specific biological markers, like certain genes and proteins, that can tell us more about why some individuals with TLE experience memory loss. By studying these markers in blood and brain tissue, we hope to develop better ways to predict memory problems and guide personalized treatments for patients.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 21 and older with temporal lobe epilepsy, particularly those with pharmacoresistant mesial TLE and hippocampal sclerosis, who may or may not experience memory deficits.
Not a fit: Patients without temporal lobe epilepsy or those under 21 years old would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict, prevent, or treat memory problems in adults living with temporal lobe epilepsy.
How similar studies have performed: Previous work by this team has identified some genes and proteins linked to memory function in TLE, suggesting a promising foundation for this current approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Busch, Robyn M — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Busch, Robyn M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.