Understanding Memory and Thinking Changes in Women with HIV
Evaluation of Neurobiological Mechanisms Mediating the Effect of Immune Activation on Neurocognitive Impairment and the Role of Psychosocial Factors Among Women Living with HIV
This project looks at how immune system activity and life experiences affect memory and thinking skills in women living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11122319 on NIH RePORTER |
What this research studies
Many women living with HIV experience changes in their memory and thinking, even when their virus is well-controlled. This project aims to understand why this happens by looking at how ongoing immune system activity and social factors like stress or stigma might play a role. We are using existing information and samples from a large group of women with HIV to explore the brain pathways involved. Our goal is to uncover the connections between the immune system, life experiences, and cognitive changes.
Who could benefit from this research
Good fit: This project focuses on understanding cognitive changes in women living with HIV, particularly those who have participated in the Women's Interagency HIV Study (WIHS).
Not a fit: Patients who are not women living with HIV or who do not experience cognitive impairment related to HIV may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat memory and thinking problems for women living with HIV.
How similar studies have performed: Previous studies have shown links between immune activation and cognitive issues in HIV, and this project builds upon that knowledge by exploring specific neurobiological pathways and psychosocial factors.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Wheeler, Pariya Fazeli — University of Alabama at Birmingham
- Study coordinator: Wheeler, Pariya Fazeli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.