Understanding Melanoma Spread, Especially to the Brain
A High-Throughput Model for Human Melanoma
This research uses a special mouse model to better understand how melanoma spreads, particularly to the brain, so we can find new ways to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10980507 on NIH RePORTER |
What this research studies
Melanoma is a serious skin cancer, and its spread to the brain is a major challenge for patients. Our team has developed a unique mouse model that closely mimics how human melanoma develops and spreads, including to the lungs and brain. This model allows us to study the specific genetic changes that drive melanoma growth and metastasis. By identifying these key changes, we aim to discover new targets for medicines. The ultimate goal is to develop more effective treatments for patients with advanced melanoma.
Who could benefit from this research
Good fit: This foundational research aims to benefit all patients affected by melanoma, particularly those at risk for or experiencing brain metastases.
Not a fit: Patients seeking immediate new treatments will not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the identification of new therapeutic targets, potentially resulting in new treatments that prevent or stop melanoma from spreading, especially to the brain.
How similar studies have performed: This project develops a novel mouse model that closely mimics human melanoma, providing a new and powerful platform for discovery.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Holmen, Sheri L — Utah State Higher Education System--University of Utah
- Study coordinator: Holmen, Sheri L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.