Understanding mechanical biomarkers for diagnosing normal pressure hydrocephalus
Official title: Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus
Funded at Mayo Clinic Rochester · NIH-11085251 · Data updated 2026-11-12
This study is looking at how the stiffness of the brain can help doctors better diagnose normal pressure hydrocephalus (NPH), a condition that can look like other types of dementia, so that patients can get the right treatment and improve their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $395,430 |
| NIH project number | 5R01AG081584-02 |
| Project ID | NIH-11085251 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing symptoms of dementia, particularly those who may have normal pressure hydrocephalus.
✕Less likely to help
Patients with irreversible forms of dementia or those not exhibiting symptoms of normal pressure hydrocephalus may not benefit from this research.
What this research studies
This research investigates how mechanical properties of the brain can help accurately diagnose normal pressure hydrocephalus (NPH), a condition that can mimic other forms of dementia. By using advanced imaging techniques like magnetic resonance elastography (MRE), the study aims to identify specific patterns in brain stiffness that differentiate NPH from other age-related disorders. The goal is to improve diagnostic accuracy and predict treatment outcomes for patients who may benefit from surgical intervention. If successful, this research could lead to better management of NPH and improved quality of life for patients.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment outcomes for patients with normal pressure hydrocephalus.
How similar studies have gone: Previous research has shown promise in using mechanical biomarkers for diagnosing NPH, but this approach is still being refined and tested.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Murphy, Matthew Christopher — Mayo Clinic Rochester
- Study coordinator: Murphy, Matthew Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.