Understanding maternal immune responses during pregnancy and vaccination
Research Project 1 - The pregnancy ImmunOME
This study looks at how COVID-19 vaccines and other shots affect the immune system of pregnant women at different stages of their pregnancy, helping us understand how these vaccines might benefit both moms and their babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11058435 on NIH RePORTER |
What this research studies
This research investigates how the immune system of pregnant women responds to COVID-19 vaccines and other vaccinations throughout different trimesters of pregnancy. By analyzing blood samples and other biological materials from mothers before and after vaccination, the study aims to identify changes in immune responses that could affect both the mother and the fetus. The research employs advanced techniques such as single-cell RNA sequencing and proteomics to capture detailed immune profiles. This comprehensive approach will help clarify the benefits and risks associated with maternal vaccination.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are receiving or have received COVID-19 vaccinations during their pregnancy.
Not a fit: Patients who are not pregnant or those who have not received any vaccinations during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of maternal immunity, leading to improved vaccination strategies for pregnant women and better health outcomes for both mothers and infants.
How similar studies have performed: Previous research has shown promising results in understanding maternal immune responses to vaccinations, indicating that this approach could yield valuable insights.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Edlow, Andrea Goldberg — Massachusetts Institute of Technology
- Study coordinator: Edlow, Andrea Goldberg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.