Understanding Lymphatic System Health and Disease
Molecular Mechanisms Controlling Lymphatic Vascular Function in Health and Disease
This research explores how the body's lymphatic system works and what goes wrong in conditions like heart disease and metabolic disorders, hoping to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11095964 on NIH RePORTER |
What this research studies
Our bodies have a lymphatic system that helps manage fluid balance and absorb fats, and when it works well, it can improve outcomes for people with heart and metabolic problems. We are looking closely at the tiny parts of lymphatic cells to understand how they function normally and what changes occur during illness. By identifying key molecules that control the lymphatic system, we hope to discover new targets for medicines. This work builds on past findings about how certain proteins and small RNA molecules affect lymphatic health.
Who could benefit from this research
Good fit: This foundational research is relevant to adults aged 21 and older who are affected by or at risk for cardiovascular and metabolic disorders.
Not a fit: Patients without cardiovascular or metabolic conditions may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiovascular and metabolic diseases by improving lymphatic system function.
How similar studies have performed: Previous work by this team has already identified important regulators of lymphatic function, indicating a strong foundation for this ongoing research.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.