Understanding Lymphatic Issues in Newborns
Epigenetic regulation of lymphatic development
This research aims to understand why some newborns develop a dangerous fluid buildup in their lungs, which can cause severe breathing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11109482 on NIH RePORTER |
What this research studies
Many newborns experience a serious condition where fluid, called chyle, collects around their lungs, leading to severe breathing difficulties and high mortality rates. Although this problem has been recognized for centuries, we still don't fully understand why it happens or how to treat it effectively. This project explores how lymphatic vessels, which are crucial for draining fluid from the lungs, develop and function in newborns. By studying the genetic and cellular processes that guide lymphatic vessel formation, we hope to uncover the root causes of these life-threatening conditions.
Who could benefit from this research
Good fit: This foundational research is relevant to newborns experiencing congenital or neonatal accumulation of chyle in the pleural space, often associated with severe respiratory distress.
Not a fit: Patients without congenital or neonatal lymphatic development issues or chyle accumulation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat severe lung issues caused by lymphatic problems in newborns.
How similar studies have performed: While the specific mechanisms for these conditions remain largely undefined, this work builds upon historical observations and recent findings regarding prenatal lymphatic function.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Trivedi, Chinmay M — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Trivedi, Chinmay M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.