Understanding Lupus Genetics and its Viral Connections
Genetic Linkage in Lupus
This research explores how our genes and the Epstein-Barr virus might work together to cause lupus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11091419 on NIH RePORTER |
What this research studies
This project looks closely at the genetic factors that contribute to systemic lupus erythematosus, also known as lupus. We know there are many specific areas in our DNA that increase the risk of developing lupus. This work suggests that the Epstein-Barr virus, a common virus, might play a key role by interacting with these genetic risk areas. Specifically, certain proteins from the virus appear to bind to these lupus-related genetic locations, especially within immune cells called B cells. By understanding these interactions, we hope to uncover how lupus begins and progresses.
Who could benefit from this research
Good fit: This research focuses on understanding the genetic makeup of individuals with systemic lupus erythematosus.
Not a fit: Patients whose condition is not related to systemic lupus erythematosus would likely not directly benefit from this specific genetic research.
Why it matters
Potential benefit: This work could lead to new ways to prevent or treat lupus by targeting the genetic and viral factors involved.
How similar studies have performed: Previous research has identified many genetic risk factors for lupus, and there is growing evidence supporting a role for the Epstein-Barr virus in the disease.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Kottyan, Leah Claire — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Kottyan, Leah Claire
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.