Understanding Lung Repair After Severe Flu Infection
PRC2 independent role of Ezh2 in regulation of basal cell dynamics post-influenza virus infection
This research looks at how our lungs heal after a severe flu infection, especially when the repair process doesn't work quite right.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11177934 on NIH RePORTER |
What this research studies
When you get a severe flu, like H1N1, it can seriously damage your lungs. While your body tries to fix this damage, sometimes the repair isn't complete, leading to scar-like tissue and breathing problems, similar to conditions like COPD. Our team is studying specific cells in the lung, called basal cells, and a protein called Ezh2, which seems to play a role in this incomplete healing process. We want to understand how Ezh2 works in these cells to improve lung repair after severe infections.
Who could benefit from this research
Good fit: This research is most relevant to patients who have experienced severe lung damage from influenza or suffer from chronic lung conditions like COPD that involve similar repair issues.
Not a fit: Patients without severe lung damage from influenza or related chronic lung conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to help lungs heal better after severe flu, potentially preventing long-term breathing issues.
How similar studies have performed: While some aspects of basal cell behavior post-infection have been observed, the specific role of Ezh2 independent of its usual function in this context is a novel area of exploration.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yao, Changfu — Cedars-Sinai Medical Center
- Study coordinator: Yao, Changfu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.