Understanding Lung Problems After Stem Cell Transplants in Children
TRANSPIRE: A Prospective Cohort Study of Lung Injury After Hematopoietic Stem Cell Transplant in Children.
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11143800
This project aims to better understand and find ways to diagnose lung problems that can happen in children after they receive a stem cell transplant.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11143800 on ClinicalTrials.gov |
What this research studies
Many children who receive a stem cell transplant can develop serious lung issues, like bronchiolitis obliterans, which are hard to detect early, especially in very young children who cannot do breathing tests. This project will follow children at six major transplant centers in the U.S. to collect detailed information about their lung health over time. By carefully tracking their progress and symptoms, we hope to identify early signs and risk factors for these lung complications. This will help us learn how often these problems occur and what they look like in different children.
Who could benefit from this research
Good fit: Children receiving hematopoietic stem cell transplants for various conditions, including non-malignant hematologic disorders, would be ideal candidates for this type of research.
Not a fit: Patients who have not undergone a hematopoietic stem cell transplant or are adults would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate diagnosis of lung injury in children after stem cell transplants, potentially improving their chances for better lung function and survival.
How similar studies have performed: While the specific challenge of diagnosing bronchiolitis obliterans in young children after HSCT is significant, similar cohort approaches have been successful in identifying risk factors and disease patterns in other rare conditions.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIES, STELLA MARGARET — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: DAVIES, STELLA MARGARET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.