Understanding Lung Problems After COVID-19
Analysis of immunologic mechanisms in patients with chronic lung disease after acute COVID infection
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11170397
This project looks at why some people have long-lasting lung issues after a COVID-19 infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11170397 on ClinicalTrials.gov |
What this research studies
Many individuals experience ongoing lung problems, like breathing difficulties and changes seen on X-rays, long after their initial COVID-19 illness. We want to understand what causes this continued inflammation and scarring in the lungs. Our team is examining the immune responses and other factors in the lung's air sacs of patients who have developed these chronic conditions. By studying these patterns, we hope to uncover the underlying reasons for persistent lung damage after COVID-19.
Who could benefit from this research
Good fit: Ideal candidates would be patients experiencing chronic lung symptoms and changes in their lungs following an acute COVID-19 infection.
Not a fit: Patients without a history of COVID-19 infection or those who have fully recovered from acute COVID-19 without lasting lung issues may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat or prevent the long-term lung damage experienced by many after COVID-19.
How similar studies have performed: While the specific mechanisms of long COVID lung disease are still being uncovered, other studies have shown that persistent immune activation can contribute to chronic inflammation in various viral infections.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TWIGG, HOMER L — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: TWIGG, HOMER L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus