Understanding lung injury risks in sepsis survivors
Predisposition for Lung Injury in Sepsis Survival
['FUNDING_CAREER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11067789
This study is looking at how surviving sepsis can lead to lung problems later on, like pneumonia, and it’s using mice to figure out how certain immune responses might cause these issues, with the hope of finding better treatments to protect your lungs after sepsis.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11067789 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term pulmonary complications that can occur in patients who survive sepsis. It focuses on understanding how certain immune responses can lead to increased risks of lung injuries, such as pneumonia and respiratory failure, after recovery from sepsis. The research utilizes a mouse model to study the mechanisms behind these complications, particularly looking at the role of specific proteins that signal inflammation. By identifying these pathways, the research aims to pave the way for targeted therapies to prevent lung injuries in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently survived sepsis and are experiencing or at risk for pulmonary complications.
Not a fit: Patients who have not experienced sepsis or those with pre-existing severe lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of lung injuries in patients recovering from sepsis.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in sepsis, but this specific approach to studying lung injury mechanisms is relatively novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENSTAEDT, SCOTT JOHN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: DENSTAEDT, SCOTT JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.