Understanding Lung Healing in Tuberculosis
Role of Lung Repair and Regeneration Pathways in Tuberculosis
['FUNDING_R21'] · UNIVERSITY OF CHICAGO · NIH-11140997
This project explores how a specific healing pathway in the lungs helps control tuberculosis infection and prevent it from becoming active disease.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11140997 on ClinicalTrials.gov |
What this research studies
Many people carry the tuberculosis (TB) germ without getting sick, but some develop active disease later. We want to understand why some individuals stay healthy while others become ill. Our work focuses on a natural healing process in the lungs, called the BMP signaling pathway, which appears to be active during the hidden (latent) phase of TB. We believe this pathway helps repair lung damage and keeps the infection under control. By studying this, we hope to uncover how the body protects itself and what goes wrong when TB becomes active.
Who could benefit from this research
Good fit: This research aims to understand the underlying biology of tuberculosis in adults, particularly those with latent infection.
Not a fit: Patients without tuberculosis or those not interested in the fundamental mechanisms of the disease may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing latent tuberculosis infection from progressing to active disease.
How similar studies have performed: This research explores a novel pathway in tuberculosis, as the specific role of the BMP pathway in latent infection and lung repair is currently unknown.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AHMED, MUSHTAQ — UNIVERSITY OF CHICAGO
- Study coordinator: AHMED, MUSHTAQ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.