Understanding lung function loss after transplantation
Airway epithelial cell and lymphocyte interactions in chronic lung allograft dysfunction pathogenesis
This study is looking at how chronic lung allograft dysfunction (CLAD) affects lung transplant patients by examining changes in their airway cells, with the goal of finding new ways to help improve their lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11175854 on NIH RePORTER |
What this research studies
This research investigates chronic lung allograft dysfunction (CLAD), a condition that leads to progressive loss of lung function in transplant recipients. By analyzing gene expression changes in airway cells from lung transplant patients, the study aims to uncover the mechanisms behind CLAD and its associated fibrosis. The research utilizes innovative techniques to assess how hypoxia and immune responses contribute to this condition, potentially leading to new therapeutic strategies. Patients may be monitored through advanced transcriptional analysis to better understand their lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation and are experiencing or at risk for chronic lung allograft dysfunction.
Not a fit: Patients who have not received a lung transplant or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung transplant recipients, enhancing their long-term survival and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding lung transplant complications through gene expression analysis, indicating that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Greenland, John — University of California, San Francisco
- Study coordinator: Greenland, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.