Understanding Lung Function in Children with Asthma
Methylomic and metabolomic determinants of Lung Function in Asthmatics
This research looks at how genes and environment work together to affect lung function in children with asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11110492 on NIH RePORTER |
What this research studies
Asthma can lead to reduced lung growth and a decline in lung function over time, and we believe this is due to a complex mix of genetic and environmental factors. This project aims to understand how these factors interact by looking at specific changes in DNA (methylome) and body chemicals (metabolome) that are influenced by our surroundings. By combining these two types of information, we hope to find new ways to understand why some children with asthma experience a greater decline in lung function. We are focusing on specific biological pathways that our early findings suggest are important for lung health in asthmatic children.
Who could benefit from this research
Good fit: This research is relevant to children and adolescents with asthma, particularly those aged 0-20 years old.
Not a fit: Patients without asthma or those outside the specified age range may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of asthma progression, potentially helping to identify children at higher risk for lung function decline and guiding future personalized treatments.
How similar studies have performed: While previous studies have looked at either the methylome or metabolome in relation to lung function, this research is novel in its approach to simultaneously investigate both in asthmatic children.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Kachroo, Priyadarshini — Rutgers Biomedical and Health Sciences
- Study coordinator: Kachroo, Priyadarshini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.