Understanding lung disease in children with systemic juvenile idiopathic arthritis
Official title: Natural history and validation of surrogate biomarkers and patient-reported outcomes for SJIA-LD
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10977804 · Data updated 2026-11-12
This study is looking at how chronic lung disease affects children with systemic juvenile idiopathic arthritis, aiming to understand the condition better and find helpful signs that show how it's changing, so we can improve treatments for these kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $206,016 |
| NIH project number | 1R01AR084717-01 |
| Project ID | NIH-10977804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with systemic juvenile idiopathic arthritis and experiencing lung disease.
✕Less likely to help
Patients without a diagnosis of systemic juvenile idiopathic arthritis or those over the age of 11 may not benefit from this research.
What this research studies
This research focuses on chronic lung disease in children suffering from systemic juvenile idiopathic arthritis (SJIA-LD), which can lead to severe respiratory issues. The study aims to define the disease, track its progression, and identify biomarkers that indicate disease activity. By gathering patient-reported outcomes and clinical data, the research seeks to fill critical knowledge gaps that hinder effective treatment development. A multicenter cohort study has already begun, enrolling patients to gather comprehensive data on this condition.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for children with SJIA-LD.
How similar studies have gone: While research on SJIA-LD is limited, similar approaches in studying chronic lung diseases in children have shown promise in identifying effective treatments.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Schulert, Grant Sanford — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Schulert, Grant Sanford
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.