Understanding Lung Disease in Children with Systemic Juvenile Arthritis
Natural history and validation of surrogate biomarkers and patient-reported outcomes for SJIA-LD
This project aims to better understand a serious lung disease affecting children with a type of arthritis, by identifying how it progresses and what signs or symptoms can help doctors track it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11170664 on NIH RePORTER |
What this research studies
Children with systemic juvenile idiopathic arthritis can develop a severe lung disease (SJIA-LD) that currently has no proven treatments. This important work seeks to clearly define SJIA-LD and understand how it changes over time. Researchers are looking for specific markers in the blood and symptoms reported by patients that can help track the disease. By gathering this information, the goal is to make it easier to design and conduct future studies to find effective treatments for this condition.
Who could benefit from this research
Good fit: Children diagnosed with systemic juvenile idiopathic arthritis who have or are at risk for lung disease are the focus of this research.
Not a fit: Patients without systemic juvenile idiopathic arthritis or related lung complications would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work will provide clearer ways to identify and track SJIA-LD, paving the way for new and more effective treatments for affected children.
How similar studies have performed: While there are no proven effective treatments for SJIA-LD, the researchers have already developed preliminary outcome measures and identified potential markers in pilot studies, suggesting a promising foundation for this larger effort.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Schulert, Grant Sanford — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Schulert, Grant Sanford
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.