Understanding lung damage in children who have had blood stem cell transplants
Official title: Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients
Funded at University of California, San Francisco · NIH-10985546 · Data updated 2026-11-12
This study is looking at how blood stem cell transplants might cause lung problems, like pulmonary fibrosis, in kids, and it aims to find out which children are at risk so that doctors can better help them with new treatments.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $134,123 |
| NIH project number | 1R03HL171423-01A1 |
| Project ID | NIH-10985546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have undergone allogeneic hematopoietic cell transplantation.
✕Less likely to help
Patients who have not undergone hematopoietic cell transplantation or are older than 11 years may not benefit from this research.
What this research studies
This research investigates how blood stem cell transplants can lead to lung damage, specifically pulmonary fibrosis, in children. By analyzing fluid samples from the lungs and blood of pediatric patients, the study aims to identify those at risk for this condition. The research will explore the biological mechanisms behind lung injury and seek to improve strategies for selecting patients for new therapies targeting pulmonary fibrosis. This could ultimately enhance treatment outcomes for affected children.
Why it matters
Potential benefit: If successful, this research could lead to better identification and treatment options for children at risk of lung damage after blood stem cell transplants.
How similar studies have gone: Previous research has shown promise in understanding pulmonary fibrosis in adult populations, but this specific approach in pediatric patients is novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Zinter, Matthew Scott — University of California, San Francisco
- Study coordinator: Zinter, Matthew Scott
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.