Understanding lung complications in children after stem cell transplants
Pathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular Transplantation
This study is looking at why some kids who have had a stem cell transplant develop lung problems, by examining samples from their lungs to find out what germs might be causing these issues, with the hope of improving how we diagnose and treat these kids in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10771221 on NIH RePORTER |
What this research studies
This research investigates the causes of lung complications in children who have undergone hematopoietic cell transplantation (HCT). By analyzing lower respiratory samples from pediatric patients, the study aims to identify the microbial composition and potential pathogens associated with these complications. The approach utilizes advanced metagenomic sequencing technology to gain insights into the biology of lung diseases post-transplant. This understanding could lead to better diagnostic methods and targeted treatments for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who have undergone hematopoietic cell transplantation and are experiencing pulmonary complications.
Not a fit: Patients who have not undergone hematopoietic cell transplantation or those without pulmonary complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and treatment outcomes for children experiencing lung complications after HCT.
How similar studies have performed: Previous research has shown promise in understanding post-transplant complications through similar microbiome analysis approaches, indicating potential for success in this study.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Zinter, Matthew Scott — University of California, San Francisco
- Study coordinator: Zinter, Matthew Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.