Understanding lung blood vessel changes in pulmonary hypertension
Pathophysiology Core
This study is looking at how the blood vessels in the lungs change in people with idiopathic pulmonary arterial hypertension (IPAH) to better understand the disease and find important clues that could help in treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10911058 on NIH RePORTER |
What this research studies
This research investigates the changes in lung blood vessels associated with pulmonary hypertension, particularly in patients with idiopathic pulmonary arterial hypertension (IPAH). It utilizes advanced techniques such as tissue processing, immunohistochemistry, and high-throughput imaging to analyze lung samples from both human patients and animal models. The study aims to characterize the remodeling of blood vessels, assess inflammation, and isolate important molecules that could provide insights into the disease's progression. By integrating various methodologies, the research seeks to enhance our understanding of the underlying mechanisms of pulmonary hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with idiopathic pulmonary arterial hypertension or related pulmonary vascular diseases.
Not a fit: Patients with other forms of pulmonary hypertension not related to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients suffering from pulmonary hypertension.
How similar studies have performed: Previous research has shown promising results in understanding pulmonary vascular remodeling using similar methodologies, indicating potential for success in this study.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Tuder, Rubin M. — University of Colorado Denver
- Study coordinator: Tuder, Rubin M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.