Understanding LRRK2 and inflammation in Parkinson's disease
LRRK2 and inflammasome pathway in Parkinson's disease
This research explores how a protein called LRRK2 and the body's inflammatory response might contribute to Parkinson's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11144476 on NIH RePORTER |
What this research studies
Our bodies have a protein called LRRK2, which is a major risk factor for Parkinson's disease, and changes in its gene are linked to both inherited and sporadic forms of the condition. We've found that LRRK2 interacts with other proteins called NLRPs, which are part of the body's immune system and can trigger inflammation. This project aims to discover if a faulty LRRK2 protein activates these inflammatory pathways, leading to brain cell damage and the progression of Parkinson's disease. By understanding these connections, we hope to uncover new ways to protect brain cells and reduce inflammation.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with Parkinson's disease, especially those with LRRK2 mutations, in the future.
Not a fit: Patients without Parkinson's disease or related neuroinflammatory conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new targets for medications that slow or stop the progression of Parkinson's disease by controlling inflammation and LRRK2 activity.
How similar studies have performed: This project builds upon recent discoveries about LRRK2's interaction with inflammatory proteins, suggesting a novel approach to understanding Parkinson's disease.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Smith, Wanli W — Johns Hopkins University
- Study coordinator: Smith, Wanli W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.