Understanding Longevity and Disease at a Genetic Level
Genetic and Molecular Basis of Longevity
This project explores how a specific enzyme helps cells manage proteins, which could offer new insights into diseases like Alzheimer's and how our bodies fight viruses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11128529 on NIH RePORTER |
What this research studies
Our bodies have a natural way to clean up damaged proteins, and this project looks at a key enzyme called NGLY1 that helps with this process. When this cleanup system doesn't work well, it can lead to conditions like Alzheimer's disease and related dementias (ADRD). We are also exploring how this same system might be involved in how our bodies respond to viral infections, including viruses like SARS-CoV-2. By understanding these fundamental processes, we hope to uncover new ways to protect our cells and promote healthy aging.
Who could benefit from this research
Good fit: Patients with Alzheimer's disease, related dementias, or those interested in the fundamental processes of aging and viral immunity may find this research relevant.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the causes of Alzheimer's disease and related dementias, and potentially new strategies for treatment or prevention, as well as insights into antiviral defense.
How similar studies have performed: This project builds upon the researchers' own discoveries regarding the NGLY1 enzyme's role in protein editing and proteasomal capacity, extending its implications to human diseases and antiviral responses.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ruvkun, Gary B — Massachusetts General Hospital
- Study coordinator: Ruvkun, Gary B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.