Understanding long-term respiratory issues in premature infants
Official title: Long-term Endotypes of Prematurity Associated Respiratory Disease (LEOPARD)
Funded at Lurie Children's Hospital of Chicago · NIH-10804513 · Data updated 2026-11-12
This study is looking at how being born very early affects breathing problems like asthma in babies, and it’s for families of premature infants who want to understand and help prevent these issues as their children grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,070,206 |
| NIH project number | 1R01HL164570-01A1 |
| Project ID | NIH-10804513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants born prematurely (before 28 weeks of gestation) who are at risk for long-term respiratory complications.
✕Less likely to help
Patients who were not born prematurely or do not have a history of respiratory issues related to prematurity may not benefit from this research.
What this research studies
This research investigates the long-term respiratory problems faced by infants born before 28 weeks of gestation, particularly focusing on conditions like asthma and bronchopulmonary dysplasia (BPD). By analyzing genetic data from a large cohort of former premature children, the study aims to identify specific genetic pathways that contribute to these respiratory issues. The goal is to develop targeted interventions that can prevent or treat these conditions early in life. Patients will be monitored from their time in the neonatal intensive care unit (NICU) through their school years and beyond.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for respiratory diseases in premature infants.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to respiratory diseases in premature infants, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Hamvas, Aaron — Lurie Children's Hospital of Chicago
- Study coordinator: Hamvas, Aaron
Related research
Other NIH-funded projects on the same topics.
-
Long-term endotypes of prematurity-related lung disease in former preemies
A long-term study looking at why some babies born very early develop lasting breathing problems and how their genes might explain these different paths.
-
Long-term lung health after very early birth
This project looks for genetic patterns that explain why some babies born before 28 weeks have lasting breathing problems, to help people born very prematurely.
-
Household air pollution and child DNA changes tied to later lung health
A study in Guatemalan children looks at how early exposure to smoky kitchen fuel changes DNA and could influence respiratory health as they grow.
-
Butyrate-based approach to prevent vision loss in premature babies with retinopathy
A study is exploring whether increasing butyrate levels can prevent vision-damaging retinopathy in premature infants by addressing gut bacteria and metabolic pathways.
-
Genetic testing and specialist care for rare causes of chronic lung, sinus, and ear infections
This project offers stepwise genetic testing and specialty referrals to find rare inherited causes of recurring lung, sinus, and ear infections in children and adults.
-
Quantitative imaging to find chronic lung disease in high-risk patients
A project will use advanced chest CT image analysis to detect chronic lung diseases early in veterans, aiming to help people who might otherwise go undiagnosed.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.