Understanding long-term respiratory issues in premature infants
Long-term Endotypes of Prematurity Associated Respiratory Disease (LEOPARD)
['FUNDING_R01'] · LURIE CHILDREN'S HOSPITAL OF CHICAGO · NIH-10804513
This study is looking at how being born very early affects breathing problems like asthma in babies, and it’s for families of premature infants who want to understand and help prevent these issues as their children grow up.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LURIE CHILDREN'S HOSPITAL OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10804513 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term respiratory problems faced by infants born before 28 weeks of gestation, particularly focusing on conditions like asthma and bronchopulmonary dysplasia (BPD). By analyzing genetic data from a large cohort of former premature children, the study aims to identify specific genetic pathways that contribute to these respiratory issues. The goal is to develop targeted interventions that can prevent or treat these conditions early in life. Patients will be monitored from their time in the neonatal intensive care unit (NICU) through their school years and beyond.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants born prematurely (before 28 weeks of gestation) who are at risk for long-term respiratory complications.
Not a fit: Patients who were not born prematurely or do not have a history of respiratory issues related to prematurity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for respiratory diseases in premature infants.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to respiratory diseases in premature infants, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- LURIE CHILDREN'S HOSPITAL OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAMVAS, AARON — LURIE CHILDREN'S HOSPITAL OF CHICAGO
- Study coordinator: HAMVAS, AARON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene