Understanding Long-term Kidney Transplant Outcomes for Patients with APOL1 Gene Variations
7/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
This research looks at how a specific gene in kidney donors might affect how long transplanted kidneys last in patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11127606 on NIH RePORTER |
What this research studies
This project is part of a larger effort called the APOLLO Network, which is gathering information from many kidney transplant patients and donors. We are carefully observing how transplanted kidneys perform over time, especially focusing on a specific gene called APOL1 found in the donor kidney. By collecting DNA samples from both recipients and donors, we hope to learn if certain variations in the APOL1 gene might influence the long-term success of a kidney transplant. This information could help us better understand why some transplanted kidneys last longer than others.
Who could benefit from this research
Good fit: Patients who have received a kidney transplant or are considering donating a kidney may be ideal candidates for similar future research.
Not a fit: Patients not involved in kidney transplantation, either as recipients or donors, would not directly benefit from this specific observational research.
Why it matters
Potential benefit: If successful, this work could help doctors better predict the long-term success of kidney transplants and personalize care for patients.
How similar studies have performed: While previous smaller studies have hinted at the role of APOL1, this is the largest observational effort to date to understand its impact on kidney transplant outcomes.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Poggio, Emilio Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Poggio, Emilio Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.