Understanding long-term immunity after yellow fever vaccination
Long Term Immunity Following Yellow Fever Vaccination
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-10804598
This study is looking at how well the yellow fever vaccine works over time, especially for people who might not have enough antibodies years after getting the shot, to help decide if booster shots are needed for better protection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10804598 on ClinicalTrials.gov |
What this research studies
This research investigates how the yellow fever vaccine (17D) induces and maintains immunity in individuals over time. It focuses on the presence of neutralizing antibodies in vaccinated individuals, particularly those who may not have detectable antibodies more than ten years after vaccination. By analyzing data from various populations, the study aims to clarify the effectiveness of the vaccine and the need for booster shots. This could help inform vaccination strategies and public health policies in regions affected by yellow fever.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received the yellow fever vaccine and are over 21 years old.
Not a fit: Patients who have never been vaccinated against yellow fever or those living in non-endemic areas without exposure to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and better protection against yellow fever outbreaks.
How similar studies have performed: Previous research has shown varying levels of immunity in vaccinated individuals, indicating that this area of study is both relevant and necessary for understanding vaccine efficacy.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MESSER, WILLIAM — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: MESSER, WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.