NIH-funded research NIH-funded research

Understanding long-term effects of COVID-19

Official title: Markers and Mechanisms of PASC

Funded at James H Quillen VA Medical Center · NIH-10924406 · Data updated 2026-11-12

This study is looking at the long-term health issues some people, especially veterans, face after recovering from COVID-19, to find out what causes these ongoing symptoms and how to help them feel better.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionJames H Quillen VA Medical Center
NIH-funded
Lab location1 site (Mountain Home, United States)
Project startOctober 1, 2024
Project endSeptember 30, 2028
Funding year2025
NIH project number1I01BX006421-01A1
Project IDNIH-10924406 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who have recovered from COVID-19 but continue to experience symptoms for more than four weeks.

Less likely to help

Patients who have not had COVID-19 or those who have fully recovered without any lingering symptoms may not benefit from this research.

What this research studies

This research investigates the long-term health effects experienced by some individuals after recovering from COVID-19, known as post-acute sequelae of COVID-19 (PASC). It aims to identify specific biomarkers and understand the underlying biological mechanisms that contribute to these ongoing symptoms. By studying the immune responses and inflammatory markers in COVID-19 survivors, the research seeks to provide insights into how to better manage and treat those suffering from PASC. The study focuses particularly on veterans who have experienced COVID-19, aiming to improve their long-term health outcomes.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients suffering from long-term COVID-19 symptoms.

How similar studies have gone: Other research has shown promising results in understanding the long-term effects of viral infections, making this approach both relevant and necessary.

Where this research is happening

  • James H Quillen VA Medical Center
    Mountain Home, United States
    Active

Researchers

  • Principal investigator: Moorman, Jonathan P — James H Quillen VA Medical Center
  • Study coordinator: Moorman, Jonathan P

Related research

Other NIH-funded projects on the same topics.

  • Understanding how stress and arousal relate to tinnitus using eye and skin signals

    Researchers will test whether easy-to-measure signals like pupil size and skin conductance can reflect how distressing tinnitus feels in adults, especially Veterans.

    NIH research James H Quillen VA Medical Center · Mountain Home, United States · NIH-11511699

  • Modulating a brain receptor to help with PTSD and alcohol abuse

    This study is looking at how PTSD and alcohol use problems are connected in Veterans, and it aims to find new ways to help improve thinking and decision-making by looking at how the brain works, which could lead to better treatments for these conditions.

    NIH research James H Quillen VA Medical Center · Mountain Home, United States · NIH-11098478

  • Exploring the use of a protein to improve heart recovery after injury.

    This study is looking at how a small protein called ubiquitin might help the heart heal better after it's been damaged from not getting enough blood, like during a heart attack, by reducing inflammation and scarring.

    NIH research James H Quillen VA Medical Center · Mountain Home, United States · NIH-11092679

  • Understanding bothersome ringing in the ears using body responses

    This project aims to find new ways to measure how much ringing in the ears, or tinnitus, bothers Veterans, using physical signs like pupil changes and skin responses.

    NIH research James H Quillen VA Medical Center · Mountain Home, United States · NIH-11072062

  • Evaluating how the body's response relates to distressing tinnitus.

    This study is looking at how the body's reactions to stress are connected to the distress caused by tinnitus in Veterans, and it aims to find better ways to understand and help those who experience this condition.

    NIH research James H Quillen VA Medical Center · Mountain Home, United States · NIH-10928371

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.