Understanding liver signals that cause inflammation and scarring
Deciphering Epithelial Signals in the Liver to Drive Inflammation and Fibrosis
This study is looking at how certain signals in liver cells affect the body's healing process after injury, which could help us find better treatments for liver problems like cirrhosis, making it easier for patients to get personalized care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10862800 on NIH RePORTER |
What this research studies
This research investigates how specific signaling pathways in liver cells influence the body's response to injury, particularly focusing on the roles of Yap, Taz, and Cyr61. By examining how these signals affect non-parenchymal cells, the study aims to uncover mechanisms that lead to liver inflammation and fibrosis. The goal is to improve treatment strategies for conditions like cirrhosis by identifying targeted therapies based on these signaling pathways. Patients may benefit from advancements in personalized medicine as a result of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver conditions such as cirrhosis or those experiencing liver injury.
Not a fit: Patients with non-liver related conditions or those without any liver injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for liver diseases, particularly cirrhosis.
How similar studies have performed: Previous research has shown promising results in understanding liver signaling pathways, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Yimlamai, Dean — Yale University
- Study coordinator: Yimlamai, Dean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.